Blanchots has a unique soil composition, combining typical Chablis Kimmeridgian limestone with a layer of white clay. Blanchots takes its name from this white clay which retains moisture and protects the vines from hydric stress. The Chardonnay grapes are notably well balanced, producing wines of remarkable elegance. Domaine Laroche owns 4. While we expected an early vintage due to a very warm spring, we got a moderate summer and harvest took place in mid-September. Grapes were fully ripe and weather conditions very satisfactory. Refined style with good balance of delicate white fruit flavor and fine acidity. Good depth and long finish. Blanchots offers far much after 5 years in bottle and needs 10 to 12 years in bottle to develop fully. Review your lists of assets.

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Marge had a few hard and fast rules. Her apartment had to have high-speed Internet. And the community needed to have an active bridge club. Lucky for us at ViewPointe, we met both of those requirements. In fact, Marge is a member of two bridge clubs; one on our campus and one she travels to off site. After being in independent living in Arizona, Marge agreed it was time to be nearer to her son and daughter-in-law.

So, how did they come to choose us? We also learned from my sister-in-law that a convenient location helps. ViewPointe is about half-a-mile from our house. We did look at other communities but what kept us coming back to ViewPointe was the incredible friendliness and helpfulness of the entire staff. Everyone was superb. Most importantly, we thought we would get excellent care for mom. That has been confirmed every day. That provided an instant feeling of familiarity and comfort.

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Launched online in , the composer biography database is in continuous development. Know more. A French composer born in in Bucarest who died in He experimented many stylistic innovations: electroacoustics, paradoxical and atypical groupings, jazz, spatialisation and aleatory writing. He especially cultivated stage music and became musical director for the Ballets Roland Petit and the Paris Opera. A conductor, in he founded and directed the instrumental ensemble Ars Nova.

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An exception was the one in the quartier where I lived with my family for five years, until On Sundays, the baker, Bob, worked without sleep. Late-night carousers started appearing at three in the morning to ask for a hot baguette, swaying on tiptoe at a high ventilation window by the oven room, a hand outstretched with a euro coin. By nine, a line extended down the street, and the shop, when you finally got inside, was loud from people and from music being played at high volume.

Everyone shouted to be heard—the cacophonous hustle, oven doors banging, people waving and trying to get noticed, too-hot-to-touch baguettes arriving in baskets, money changing hands. Everyone left with an armful and with the same look, suspended between appetite and the prospect of an appetite satisfied. It was a lesson in the appeal of good bread—handmade, aromatically yeasty, with a just-out-of-the-oven texture of crunchy air.

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To support our nonprofit science journalism, please make a tax-deductible gift today. For the first time, one of the many COVID vaccines in development has protected an animal, rhesus macaques, from infection by the new coronavirus, scientists report. The vaccine, an old-fashioned formulation consisting of a chemically inactivated version of the virus, produced no obvious side effects in the monkeys, and human trials began on 16 April.

Researchers from Sinovac Biotech , a privately held Beijing-based company, gave two different doses of their COVID vaccine to a total of eight rhesus macaques. The monkeys given the highest dose of vaccine had the best response: Seven days after the animals received the virus, researchers could not detect it in the pharynx or lungs of any of them. A peer-reviewed version of the study was published on 6 May by Science.

In contrast, four control animals developed high levels of viral RNA in several body parts and severe pneumonia. What I like most is that many vaccine producers, also in lower—middle-income countries, could make such a vaccine. But Douglas Reed of the University of Pittsburgh, who is developing and testing COVID vaccines in monkey studies, says the number of animals was too small to yield statistically significant results.

His team also has a manuscript in preparation that raises concerns about the way the Sinovac team grew the stock of novel coronavirus used to challenge the animals: It may have caused changes that make it less reflective of the ones that infect humans. The study also addressed worries that partial protection could be dangerous. Earlier animal experiments with vaccines against the related coronaviruses that cause severe acute respiratory syndrome and Middle East respiratory syndrome had found that low antibody levels could lead to aberrant immune responses when an animal was given the pathogens, enhancing the infection and causing pathology in their lungs.

SARS-CoV-2 seems to accumulate mutations slowly; even so, variants might pose a challenge for a vaccine.

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